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KMID : 0545120120220081161
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Journal of Microbiology and Biotechnology
2012 Volume.22 No. 8 p.1161 ~ p.1164
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Effect of Cordycepin Purified from Cordyceps militaris on Th1 and Th2 Cytokines in Mouse Splenocytes
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Jeong Min-Ho
Seo Min-Jeong
Park Jeong-Uck
Kang Byoung-Won
Kim Kyoung-Sook
Lee Jae-Yun
Kim Gi-Young
Kim Jung-In
Choi Yung-Hyun
Kim Kwang-Hyuk
Jeong Yong-Kee
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Abstract
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Cordycepin was purified from a mushroom, Cordyceps militaris, and its effect on Th1 and Th2 cytokines was examined. The level of cytokine induction in mouse splenocytes was estimated after co-inoculation of purified cordycepin and LPS. When 5 μg/ml of purified cordycepin was exposed to mouse splenocytes for 72 h, the level of a Th1 cytokine IL-12 increased by 2.9-fold. The addition of the purified cordycepin to splenocytes also increased the level of Th2 cytokines, IL-4 and IL-10, by 1.9- and 1.8- fold, respectively. Therefore, cordycepin increases the cytokine levels and may contribute to the up-regulation of cellular and humoral immunity.
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KEYWORD
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Cordycepin, Cordyceps militaris, IL-4, IL-10, IL-12
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